Subject to some change during the course of the semester.
| Meetings: | TuTh 8-9:15am, GOS-2154 |
| Recitation | Monday 10-10:50am, GOS-1305 |
| Credits | 3 |
| Required text | Essential Genetics, 7th ed, by Hartl and Jones |
| iClicker will be required. | |
| Instructor: | Michael Osier |
| Office: | 08-1338 |
| Schedule | |
| Contact: | mvoscl@rit.edu |
Monday recitation |
Tuesday lecture |
Thursday lecture |
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| Week 1 - Jan 10 | Introduction | Why study genetics?; Phenotypic Variation | Mendel and Darwin (Chapter 2.1-2.6; Chapter 15.1-15.2, look over OMIM) | ||||
| Week 2 - Jan 17 | Online activity this week - NIH Genetic Testing Registry | Quiz 1 | Genome structures; Organization of the Chromosome; Mitosis and Meiosis; Mutation and Repair; Eukaryotic gene structure (Chapters 3.1-3.5, 6.1-6.5, 12.1-12.6) | Polymorphism; Model organisms | |||
| Week 3 - Jan 24 | CoT in the Act by Dr. Rothman | Quiz 2 | Sex-linked inheritance; Sex determination and the Lyons hypothesis (Chapters 3.6, 5.1-5.2) | Trancription, splicing, and translation (Chapter 8) | |||
| Week 4 - Jan 31 | Activity: sex-linked Drosophila phenotypes, Exam review | Exam 1 | Prokaryotic gene expression (Chapter 9.1-9.3) | ||||
| Week 5 - Feb 7 | Exam 1 followup | Quiz 3 | Mapping prokaryotic genes (Chapter 7.1-7.5) | Eukaryotic gene expression (Chapter 9.4-9.7) | |||
| Week 6 - Feb 14 | Parada et al., 2002 | Quiz 4 | Independent assortment (Chapter 2.3-2.4, 3.7 [just Chi-square Goodness-of-Fit], Chapter 4.1-4.2) | Independent assortment (Chapter 2.3-2.4, 3.7 [just Chi-square Goodness-of-Fit], Chapter 4.1-4.2) | |||
| Week 7 - Feb 21 | Online activity this week - Prokaryotic mapping practice worksheet | Quiz 5 | Tetrad analysis (4.5 [not including section on Gene Conversion]) | Linkage (Chapter 4.1-4.2, 4.5 [not including section on Gene Conversion]) | |||
| Week 8 - Feb 28 | Exam review | Exam 2 | Exam 2 followup | ||||
| Week 9 - Mar 7 | Spring Break | ||||||
| Week 10 - Mar 14 | Mid-semester review | Segregration analysis; start Eukaryotic gene mapping (Chapter 2.5, 5.1-5.3, 4.1-4.3) | Eukaryotic gene mapping; Karyotype analysis (Chapters 5.1-5.3, 4.1-4.3) | ||||
| Week 11 - Mar 21 | Activity: finding double-recombinants | Quiz 6 | Quantitative genetics (Chapters 15.1-15.2, 15.4-15.5) | Introduction to Population Genetics: Random mating, non-random mating, and HWE (Chapters 14.2-14.3, 14.9) | |||
| Week 12 - Mar 28 | Patsalis et al. paper; Xu et al. paper | Activity: Forensics and HWE | Quiz 7 | Activity: Random genetic drift; Random Genetic Drift (Chapters 14.2-14.3, 14.9) | |||
| Week 13 - Apr 4 | Exam review | Exam 3 | HWE and selection (Chapters 14.2-14.3, 14.9) | ||||
| Week 14 - Apr 11 | Exam 3 followup | Quiz 8 | Complementation (pp 17-19 for Complementation), Activity: Epistasis | Pleiotropy and Penetrance and Phenocopies, oh my! (Chapter 2.6-2.7) | |||
| Week 15 - Apr 18 | Lyons, Cox, and Dancis paper | Quiz 9 | Catchup, open course review | Activity: Doing the pathway shuffle (Genetics board game) | |||
| Week 16 - Apr 25 | Exam review | Exam week | |||||
| Quizzes (2 points each x 9) | 18% |
| Participation | 12% |
| Exam 1 | 14% |
| Exam 2 | 18% |
| Exam 3 | 18% |
| Final Exam | 20% |
| Total | 100% |
|---|
If your final exam grade is higher than your average for the first three exams, your final exam grade will replace
your lowest grade in Exams 1 through 3. So if you earn 90% on your final, and your exam average was 83%, and your
lowest grade was a 70%, the 90% will replace the 70%, plus you get a 90% on the final.
There will be no other
makeup assignments without extreme circumstances.
| A | [95-100] |
| A- | [90-95) |
| B+ | [86.7-90) |
| B | [83.4-86.7) |
| B- | [80-83.4) |
| C+ | [76.7-80) |
| C | [73.4-76.7) |
| C- | [70-73.4) |
| D | [60-70) |
| F | <60 |
Participation will be determined based upon a combination of factors, including but not limited to, attending sessions on time, participating in all iClicker questions for the day, and properly wearing a mask covering both the nose and mouth throughout the session.
I will be using iClicker to make our class time more engaging. This will help me understand what you know, give everyone a chance to participate, and increase how much you learn in class. This will also provide you with feedback on how well you are comprehending course concepts, and help you master challenging concepts.
You are required to participate with the iClicker student app on a smartphone, tablet or laptop in a timely fashion. It is also your responsibility to regularly check your iClicker records for any discrepancies.
You can use an existing iClicker account if you have one...please do not create a new account if you already have one. If you do not have an account yet, you can create a new iClicker account using the instructions here. There is a fee for using the iClicker service. Subscriptions can be purchased within the app.
Next, you can add our course per the instructions here. The course will be under "Biology" and named "BIOL-321 Genetics Osier".
The below homework questions are not required, but may be reflective of some questions on quizzes and exams. With the exception of dates without assigned problems, for every completed homework assignment submitted on paper in handwriting before the start of the following class (e.g. Homework for Week 1 due Tuesday of Week 2), students will earn 1/2 bonus point toward their final grade. No late submissions will be accepted for bonus, but feedback will be given as soon as possible.
All numbers below are Concepts in Action problems from the end of the corresponding chapter. "2.1" corresponds to Chapter 2, first Concept in Action problem. All even numbered problems have answers in the back of the text. Problems from outside the textbook may also be indicated.
| Week Assigned | Week Due | Assignment |
|---|---|---|
| 1 | 2 | 2.1, 2.2, 2.5, 2.16, 2.20; Search OMIM for a disease of interest to you...in no more than one-half page, describe what is known about the genetics of this human trait. |
| 2 | 3 | 3.2, 3.8, 6.4, 6.6, 6.8, 6.10 |
| 3 | 4 | 2.18, 3.10, 3.12, 5.4, 5.6, 5.8, 8.2, 8.6, 8.8, 8.14, 8.20, 12.2, 12.6, 12.8, 12.12, 12.16 |
| 4 | 5 | 9.2, 9.16, 9.18 |
| 5 | 6 | 9.6, 7.10, 7.14, 7.18, 7.20 |
| 6 | 7 | 3.16, 3.18 |
| 7 | N/A | None |
| 8 | 10 | 4.2, 4.6, 4.8, 4.10 |
| 9 | N/A | None |
| 10 | 11 | 2.8, 2.9, 2.10, 2.21, 4.20 a & b, 5.12 |
| 11 | 12 | 14.2, 14.4, 14.6, 14.8, 14.10, 14.12 |
| 12 | N/A | None |
| 13 | 14 | Worksheet in myCourses |
| 14 | 15 | 2.12, 2.14, 2.17, 4.13, 4.16, 4.20 (a and b), 15.2, 15.4, 15.10, 15.12, 15.20 |
| 15* | 16* | 2.3, 2.11, 2.15, 4.17, 9.13, 9.20, 12.9, 12.11, 14.9, 14.17, 2.13, 4.11, 4.14, 4.19, 9.15, 12.17, 14.11, 14.13, 14.15, 15.5 |
No electronics except for a calculator. The calculator must not be a graphing or programmable calculator. No caps or hats.
Quizzes will be allowed ten minutes starting exactly at the start of class.
There will be one makeup for any exam or quiz, on a date and time to be determined by the instructor. Please email the instructor as soon as possible if you are unable to make an exam or quiz.
Supporting information
We are all cognizant of the unique circumstances resulting from the worldwide COVID-19 SARS-2 pandemic. RIT has consulted federal, state, and local guidelines and policies to implement a safe, yet educational environment for students, staff, and faculty. These guidelines, located at http://www.rit.edu/ready/ are routinely updated as conditions change.
What do these mean for this class? As noted in the above syllabus, students are expected to be active participants in the course. I encourage your communication direclty to me about any special needs or concerns. Together we will learn in a safe and productive format.
For the duration of the semester, all in-person sessions (e.g. lecture and recitation) will require masks being properly worn to cover the mouth and nose. This will be a component of participation, above. Additionally, please observe social distancing. Students not properly wearing a mask or maintaining sufficient distancing will be asked to leave the room.
Tardiness to class or in submitting assignments/quizzes/exams due to non-compliance with Covid testing or other Institute requirements will not be excused.
COVID-19 policies will be adjusted as necessary and appropriate.
Contents last updated 4/25/22